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Purinergic receptors were first defined in 1976 and 2 years later a basis for distinguishing two types of purinoceptors, named P1 and P2 for adenosine and ATP/ADP, respectively, was proposed ( Burnstock, 1978 ). Four subtypes of P1 receptors have been cloned, namely A 1, A 2A, A 2B and A 3 (see Ralevic & Burnstock, 1998 ).

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